De lo que has puesto de título a lo que dice realmente el artículo...
"Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells" Título original.
O sea, la hormona tifoidea frena/revierte 1 tipo de cáncer.
Lo siento, pero microblogging, has cambiado por completo el sentido
•
T3 induces terminal differentiation of MB tumor cells through upregulating NeuroD1
•
T3 promotes NeuroD1 transcription by interfering with TRα1 and EZH2 interaction
•
T3 represses the growth of human and mouse tumors from multiple MB groups
•
T3-induced differentiation is an effective and safe strategy for MB treatment
Summary
Hypothyroidism is commonly detected in patients with medulloblastoma (MB). However, whether thyroid hormone (TH) contributes to MB pathogenicity remains undetermined. Here, we find that TH plays a critical role in promoting tumor cell differentiation. Reduction in TH levels frees the TH receptor, TRα1, to bind to EZH2 and repress expression of NeuroD1, a transcription factor that drives tumor cell differentiation. Increased TH reverses EZH2-mediated repression of NeuroD1 by abrogating the binding of EZH2 and TRα1, thereby stimulating tumor cell differentiation and reducing MB growth. Importantly, TH-induced differentiation of tumor cells is not restricted by the molecular subgroup of MB, suggesting that TH can be used to broadly treat MB subgroups. These findings establish an unprecedented association between TH signaling and MB pathogenicity, providing solid evidence for TH as a promising modality for MB treatment.
Graphical abstract
Figure thumbnail fx1
View Large Image Figure Viewer Download Hi-res image
Keywords
medulloblastoma
differentiation therapy
terminal differentiation
thyroid hormone
hypothyroidism
epigenetic regulation
EZH2
NeuroD1
TRα1
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References
Taylor M.D.
Northcott P.A.
Korshunov A.
Remke M.
Cho Y.J.
Clifford S.C.
Eberhart C.G.
Parsons D.W.
Rutkowski S.
Gajjar A.
et al.
Molecular subgroups of medulloblastoma: the current consensus.
Acta Neuropathol. 2012; 123: 465-472 https://doi.org/10.1007/s00401-011-0922-z
View in Article
Scopus (1438)
PubMed
Crossref
Google Scholar
Northcott P.A.
Korshunov A.
Pfister S.M.
Taylor M.D.
The clinical implications of medulloblastoma subgroups.
Nat. Rev. Neurol. 2012; 8: 340-351 https://doi.org/10.1038/nrneurol.2012.78
View in Article
Scopus (243)
PubMed
Crossref
Google Scholar
Crawford J.R.
MacDonald T.J.
Packer R.J.
Medulloblastoma in childhood: new biological advances.
Lancet Neurol. 2007; 6: 1073-1085 https://doi.org/10.1016/S1474-4422(07)70289-2
View in Article
Scopus (229)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Vanner R.J.
Remke M.
Gallo M.
Selvadurai H.J.
Coutinho F.
Lee L.
Kushida M.
Head R.
Morrissy S.
Zhu X.
et al.
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
Cancer Cell. 2014; 26: 33-47 https://doi.org/10.1016/j.ccr.2014.05.005
View in Article
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PubMed
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Full Text
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Google Scholar
Selvadurai H.J.
Luis E.
Desai K.
Lan X.
Vladoiu M.C.
Whitley O.
Galvin C.
Vanner R.J.
Lee L.
Whetstone H.
et al.
Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2(+) Granule Neuron Precursor.
Cell Rep. 2020; 31107511 https://doi.org/10.1016/j.celrep.2020.03.075
View in Article
Scopus (35)
Abstract
Full Text
Full Text PDF
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Cheng Y.
Liao S.
Xu G.
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Guo D.
Du F.
Contreras A.
Cai K.Q.
Peri S.
Wang Y.
et al.
NeuroD1 dictates tumor cell differentiation in medulloblastoma.
Cell Rep. 2020; 31107782 https://doi.org/10.1016/j.celrep.2020.107782
View in Article
Scopus (28)
Abstract
Full Text
Full Text PDF
Google Scholar
Dussault J.H.
Ruel J.
Thyroid hormones and brain development.
Annu. Rev. Physiol. 1987; 49: 321-334 https://doi.org/10.1146/annurev.ph.49.030187.001541
View in Article
PubMed
Crossref
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Bernal J.
Nunez J.
Thyroid hormones and brain development.
Eur. J. Endocrinol. 1995; 133: 390-398 https://doi.org/10.1530/eje.0.1330390
View in Article
Scopus (372)
PubMed
Crossref
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Mullur R.
Liu Y.Y.
Brent G.A.
Thyroid hormone regulation of metabolism.
Physiol. Rev. 2014; 94: 355-382 https://doi.org/10.1152/physrev.00030.2013
View in Article
Scopus (1397)
PubMed
Crossref
Google Scholar
Ishii S.
Amano I.
Koibuchi N.
The Role of Thyroid Hormone in the Regulation of Cerebellar Development.
Endocrinol. Metab. 2021; 36: 703-716 https://doi.org/10.3803/EnM.2021.1150
View in Article
Crossref
Google Scholar
Forrest D.
Vennström B.
Functions of thyroid hormone receptors in mice.
Thyroid. 2000; 10: 41-52 https://doi.org/10.1089/thy.2000.10.41
View in Article
Scopus (258)
PubMed
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Google Scholar
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Waterfall J.J.
Kim D.W.
Baek S.
Sung M.H.
Zhao L.
Park J.W.
Nielsen R.
Walker R.L.
Zhu Y.J.
et al.
Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.
Nat. Commun. 2015; 6: 7048 https://doi.org/10.1038/ncomms8048
View in Article
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PubMed
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Bonci E.A.
Bădan M.I.
Bădulescu C.I.
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Mester A.
Cosnarovici R.
Larg M.I.
Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at "Prof. Dr. Ion Chiricuta" Institute of Oncology, Cluj-Napoca.
Diagnostics. 2020; 10142 https://doi.org/10.3390/diagnostics10030142
View in Article
Scopus (2)
Crossref
Google Scholar
Paulino A.C.
Hypothyroidism in children with medulloblastoma: a comparison of 3600 and 2340 cGy craniospinal radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 2002; 53: 543-547 https://doi.org/10.1016/s0360-3016(02)02744-x
View in Article
Scopus (0)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Yang Z.J.
Ellis T.
Markant S.L.
Read T.A.
Kessler J.D.
Bourboulas M.
Schüller U.
Machold R.
Fishell G.
Rowitch D.H.
et al.
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.
Cancer Cell. 2008; 14: 135-145 https://doi.org/10.1016/j.ccr.2008.07.003
View in Article
Scopus (546)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Schuller U.
Heine V.M.
Mao J.
Kho A.T.
Dillon A.K.
Han Y.G.
Huillard E.
Sun T.
Ligon A.H.
Qian Y.
et al.
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Cancer Cell. 2008; 14: 123-134 https://doi.org/10.1016/j.ccr.2008.07.005
View in Article
Scopus (506)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Zhao H.
Ayrault O.
Zindy F.
Kim J.H.
Roussel M.F.
Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.
Genes Dev. 2008; 22: 722-727 https://doi.org/10.1101/gad.1636408
View in Article
Scopus (130)
PubMed
Crossref
Google Scholar
Schapira M.
Raaka B.M.
Das S.
Fan L.
Totrov M.
Zhou Z.
Wilson S.R.
Abagyan R.
Samuels H.H.
Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking.
Proc. Natl. Acad. Sci. USA. 2003; 100: 7354-7359 https://doi.org/10.1073/pnas.1131854100
View in Article
Scopus (162)
PubMed
Crossref
Google Scholar
Lazar M.A.
Thyroid hormone receptors: multiple forms, multiple possibilities.
Endocr. Rev. 1993; 14: 184-193 https://doi.org/10.1210/edrv-14-2-184
View in Article
Scopus (998)
PubMed
Crossref
Google Scholar
Zhang J.
Lazar M.A.
The mechanism of action of thyroid hormones.
Annu. Rev. Physiol. 2000; 62: 439-466 https://doi.org/10.1146/annurev.physiol.62.1.439
View in Article
Scopus (596)
PubMed
Crossref
Google Scholar
Platt R.J.
Chen S.
Zhou Y.
Yim M.J.
Swiech L.
Kempton H.R.
Dahlman J.E.
Parnas O.
Eisenhaure T.M.
Jovanovic M.
et al.
CRISPR-Cas9 knockin mice for genome editing and cancer modeling.
Cell. 2014; 159: 440-455 https://doi.org/10.1016/j.cell.2014.09.014
View in Article
Scopus (1377)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Amador-Arjona A.
Cimadamore F.
Huang C.T.
Wright R.
Lewis S.
Gage F.H.
Terskikh A.V.
SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.
Proc. Natl. Acad. Sci. USA. 2015; 112: E1936-E1945 https://doi.org/10.1073/pnas.1421480112
View in Article
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PubMed
Crossref
Google Scholar
Feng W.
Kawauchi D.
Körkel-Qu H.
Deng H.
Serger E.
Sieber L.
Lieberman J.A.
Jimeno-González S.
Lambo S.
Hanna B.S.
et al.
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
Nat. Commun. 2017; 814758 https://doi.org/10.1038/ncomms14758
View in Article
Scopus (97)
Crossref
Google Scholar
Stevenson T.J.
Prendergast B.J.
Reversible DNA methylation regulates seasonal photoperiodic time measurement.
Proc. Natl. Acad. Sci. USA. 2013; 110: 16651-16656 https://doi.org/10.1073/pnas.1310643110
View in Article
Scopus (129)
PubMed
Crossref
Google Scholar
Aoyama K.
Shinoda D.
Suzuki E.
Nakajima-Takagi Y.
Oshima M.
Koide S.
Rizq O.
Si S.
Tara S.
Sashida G.
Iwama A.
PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome.
Leukemia. 2021; 35: 1156-1165 https://doi.org/10.1038/s41375-020-01023-1
View in Article
Scopus (2)
Crossref
Google Scholar
Cohen R.N.
Wondisford F.E.
Hollenberg A.N.
Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements.
Mol. Endocrinol. 1998; 12: 1567-1581 https://doi.org/10.1210/mend.12.10.0188
View in Article
Scopus (64)
PubMed
Crossref
Google Scholar
Tagami T.
Park Y.
Jameson J.L.
Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor.
J. Biol. Chem. 1999; 27
Comentarios
De lo que has puesto de título a lo que dice realmente el artículo...
"Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells" Título original.
O sea, la hormona tifoidea frena/revierte 1 tipo de cáncer.
Lo siento, pero microblogging, has cambiado por completo el sentido
#6 Cuéntame
#7 acabo de modificar el comentario, ya que tanto te interesa
#8 #6 arreglao
#9 ni de lejos. El título sigue igual, pero tu a lo tuyo
Muro de pago?
#1 Con Chrome sí salta pero no uso chrome
Igualmente te copio y pego
•
T3 induces terminal differentiation of MB tumor cells through upregulating NeuroD1
•
T3 promotes NeuroD1 transcription by interfering with TRα1 and EZH2 interaction
•
T3 represses the growth of human and mouse tumors from multiple MB groups
•
T3-induced differentiation is an effective and safe strategy for MB treatment
Summary
Hypothyroidism is commonly detected in patients with medulloblastoma (MB). However, whether thyroid hormone (TH) contributes to MB pathogenicity remains undetermined. Here, we find that TH plays a critical role in promoting tumor cell differentiation. Reduction in TH levels frees the TH receptor, TRα1, to bind to EZH2 and repress expression of NeuroD1, a transcription factor that drives tumor cell differentiation. Increased TH reverses EZH2-mediated repression of NeuroD1 by abrogating the binding of EZH2 and TRα1, thereby stimulating tumor cell differentiation and reducing MB growth. Importantly, TH-induced differentiation of tumor cells is not restricted by the molecular subgroup of MB, suggesting that TH can be used to broadly treat MB subgroups. These findings establish an unprecedented association between TH signaling and MB pathogenicity, providing solid evidence for TH as a promising modality for MB treatment.
Graphical abstract
Figure thumbnail fx1
View Large Image Figure Viewer Download Hi-res image
Keywords
medulloblastoma
differentiation therapy
terminal differentiation
thyroid hormone
hypothyroidism
epigenetic regulation
EZH2
NeuroD1
TRα1
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online access
Corporate R&D Professionals: 24 hour online access
Read-It-Now
Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost. Click here to explore this opportunity.
One-time access price info
Subscribe:
Subscribe to Cancer Cell
Already a print subscriber? Claim online access
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Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
Taylor M.D.
Northcott P.A.
Korshunov A.
Remke M.
Cho Y.J.
Clifford S.C.
Eberhart C.G.
Parsons D.W.
Rutkowski S.
Gajjar A.
et al.
Molecular subgroups of medulloblastoma: the current consensus.
Acta Neuropathol. 2012; 123: 465-472
https://doi.org/10.1007/s00401-011-0922-z
View in Article
Scopus (1438)
PubMed
Crossref
Google Scholar
Northcott P.A.
Korshunov A.
Pfister S.M.
Taylor M.D.
The clinical implications of medulloblastoma subgroups.
Nat. Rev. Neurol. 2012; 8: 340-351
https://doi.org/10.1038/nrneurol.2012.78
View in Article
Scopus (243)
PubMed
Crossref
Google Scholar
Crawford J.R.
MacDonald T.J.
Packer R.J.
Medulloblastoma in childhood: new biological advances.
Lancet Neurol. 2007; 6: 1073-1085
https://doi.org/10.1016/S1474-4422(07)70289-2
View in Article
Scopus (229)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Vanner R.J.
Remke M.
Gallo M.
Selvadurai H.J.
Coutinho F.
Lee L.
Kushida M.
Head R.
Morrissy S.
Zhu X.
et al.
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
Cancer Cell. 2014; 26: 33-47
https://doi.org/10.1016/j.ccr.2014.05.005
View in Article
Scopus (224)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Selvadurai H.J.
Luis E.
Desai K.
Lan X.
Vladoiu M.C.
Whitley O.
Galvin C.
Vanner R.J.
Lee L.
Whetstone H.
et al.
Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2(+) Granule Neuron Precursor.
Cell Rep. 2020; 31107511
https://doi.org/10.1016/j.celrep.2020.03.075
View in Article
Scopus (35)
Abstract
Full Text
Full Text PDF
Google Scholar
Cheng Y.
Liao S.
Xu G.
Hu J.
Guo D.
Du F.
Contreras A.
Cai K.Q.
Peri S.
Wang Y.
et al.
NeuroD1 dictates tumor cell differentiation in medulloblastoma.
Cell Rep. 2020; 31107782
https://doi.org/10.1016/j.celrep.2020.107782
View in Article
Scopus (28)
Abstract
Full Text
Full Text PDF
Google Scholar
Dussault J.H.
Ruel J.
Thyroid hormones and brain development.
Annu. Rev. Physiol. 1987; 49: 321-334
https://doi.org/10.1146/annurev.ph.49.030187.001541
View in Article
PubMed
Crossref
Google Scholar
Bernal J.
Nunez J.
Thyroid hormones and brain development.
Eur. J. Endocrinol. 1995; 133: 390-398
https://doi.org/10.1530/eje.0.1330390
View in Article
Scopus (372)
PubMed
Crossref
Google Scholar
Mullur R.
Liu Y.Y.
Brent G.A.
Thyroid hormone regulation of metabolism.
Physiol. Rev. 2014; 94: 355-382
https://doi.org/10.1152/physrev.00030.2013
View in Article
Scopus (1397)
PubMed
Crossref
Google Scholar
Ishii S.
Amano I.
Koibuchi N.
The Role of Thyroid Hormone in the Regulation of Cerebellar Development.
Endocrinol. Metab. 2021; 36: 703-716
https://doi.org/10.3803/EnM.2021.1150
View in Article
Crossref
Google Scholar
Forrest D.
Vennström B.
Functions of thyroid hormone receptors in mice.
Thyroid. 2000; 10: 41-52
https://doi.org/10.1089/thy.2000.10.41
View in Article
Scopus (258)
PubMed
Crossref
Google Scholar
Grontved L.
Waterfall J.J.
Kim D.W.
Baek S.
Sung M.H.
Zhao L.
Park J.W.
Nielsen R.
Walker R.L.
Zhu Y.J.
et al.
Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.
Nat. Commun. 2015; 6: 7048
https://doi.org/10.1038/ncomms8048
View in Article
Scopus (99)
PubMed
Crossref
Google Scholar
Cosnarovici M.M.
Piciu A.
Bonci E.A.
Bădan M.I.
Bădulescu C.I.
Stefan A.I.
Mester A.
Cosnarovici R.
Larg M.I.
Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at "Prof. Dr. Ion Chiricuta" Institute of Oncology, Cluj-Napoca.
Diagnostics. 2020; 10142
https://doi.org/10.3390/diagnostics10030142
View in Article
Scopus (2)
Crossref
Google Scholar
Paulino A.C.
Hypothyroidism in children with medulloblastoma: a comparison of 3600 and 2340 cGy craniospinal radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 2002; 53: 543-547
https://doi.org/10.1016/s0360-3016(02)02744-x
View in Article
Scopus (0)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Yang Z.J.
Ellis T.
Markant S.L.
Read T.A.
Kessler J.D.
Bourboulas M.
Schüller U.
Machold R.
Fishell G.
Rowitch D.H.
et al.
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.
Cancer Cell. 2008; 14: 135-145
https://doi.org/10.1016/j.ccr.2008.07.003
View in Article
Scopus (546)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Schuller U.
Heine V.M.
Mao J.
Kho A.T.
Dillon A.K.
Han Y.G.
Huillard E.
Sun T.
Ligon A.H.
Qian Y.
et al.
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Cancer Cell. 2008; 14: 123-134
https://doi.org/10.1016/j.ccr.2008.07.005
View in Article
Scopus (506)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Zhao H.
Ayrault O.
Zindy F.
Kim J.H.
Roussel M.F.
Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.
Genes Dev. 2008; 22: 722-727
https://doi.org/10.1101/gad.1636408
View in Article
Scopus (130)
PubMed
Crossref
Google Scholar
Schapira M.
Raaka B.M.
Das S.
Fan L.
Totrov M.
Zhou Z.
Wilson S.R.
Abagyan R.
Samuels H.H.
Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking.
Proc. Natl. Acad. Sci. USA. 2003; 100: 7354-7359
https://doi.org/10.1073/pnas.1131854100
View in Article
Scopus (162)
PubMed
Crossref
Google Scholar
Lazar M.A.
Thyroid hormone receptors: multiple forms, multiple possibilities.
Endocr. Rev. 1993; 14: 184-193
https://doi.org/10.1210/edrv-14-2-184
View in Article
Scopus (998)
PubMed
Crossref
Google Scholar
Zhang J.
Lazar M.A.
The mechanism of action of thyroid hormones.
Annu. Rev. Physiol. 2000; 62: 439-466
https://doi.org/10.1146/annurev.physiol.62.1.439
View in Article
Scopus (596)
PubMed
Crossref
Google Scholar
Platt R.J.
Chen S.
Zhou Y.
Yim M.J.
Swiech L.
Kempton H.R.
Dahlman J.E.
Parnas O.
Eisenhaure T.M.
Jovanovic M.
et al.
CRISPR-Cas9 knockin mice for genome editing and cancer modeling.
Cell. 2014; 159: 440-455
https://doi.org/10.1016/j.cell.2014.09.014
View in Article
Scopus (1377)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Amador-Arjona A.
Cimadamore F.
Huang C.T.
Wright R.
Lewis S.
Gage F.H.
Terskikh A.V.
SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.
Proc. Natl. Acad. Sci. USA. 2015; 112: E1936-E1945
https://doi.org/10.1073/pnas.1421480112
View in Article
Scopus (116)
PubMed
Crossref
Google Scholar
Feng W.
Kawauchi D.
Körkel-Qu H.
Deng H.
Serger E.
Sieber L.
Lieberman J.A.
Jimeno-González S.
Lambo S.
Hanna B.S.
et al.
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
Nat. Commun. 2017; 814758
https://doi.org/10.1038/ncomms14758
View in Article
Scopus (97)
Crossref
Google Scholar
Stevenson T.J.
Prendergast B.J.
Reversible DNA methylation regulates seasonal photoperiodic time measurement.
Proc. Natl. Acad. Sci. USA. 2013; 110: 16651-16656
https://doi.org/10.1073/pnas.1310643110
View in Article
Scopus (129)
PubMed
Crossref
Google Scholar
Aoyama K.
Shinoda D.
Suzuki E.
Nakajima-Takagi Y.
Oshima M.
Koide S.
Rizq O.
Si S.
Tara S.
Sashida G.
Iwama A.
PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome.
Leukemia. 2021; 35: 1156-1165
https://doi.org/10.1038/s41375-020-01023-1
View in Article
Scopus (2)
Crossref
Google Scholar
Cohen R.N.
Wondisford F.E.
Hollenberg A.N.
Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements.
Mol. Endocrinol. 1998; 12: 1567-1581
https://doi.org/10.1210/mend.12.10.0188
View in Article
Scopus (64)
PubMed
Crossref
Google Scholar
Tagami T.
Park Y.
Jameson J.L.
Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor.
J. Biol. Chem. 1999; 27
#2 Yo uso Chrome y lo he podido leer.
#2 #3 solo estais viendo el resumen, no el articulo completo.
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Mi pantallazo, vaya
#4 Entonces quieres que cancele una noticia que es buena para la humanidad porque solo puedes ver una parte?
Pero sigue siendo interesante, como he dicho.